Enrofloxacin is a broad-spectrum bactericidal agent for fluoroquinolone animals. For Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, Erysipelas, Proteus, Serratia marcescens, Corynebacterium pyogenes, Porter's sepsis Bacteria, Staphylococcus aureus, Mycoplasma, Chlamydia, etc., have good effects, but have weak effects on Pseudomonas aeruginosa and Streptococcus, and weak effects on anaerobic bacteria. It has obvious antibacterial effect on sensitive bacteria. The antibacterial action mechanism of this product is to inhibit bacterial DNA gyrase and interfere with bacterial DNA replication, transcription and repair and recombination. The bacteria cannot grow and reproduce normally and die.

10% Enrofloxacin Injection is quickly and completely absorbed by intramuscular injection. The bioavailability of this product is 91.9% for pigs and 82% for dairy cows. It is widely distributed in animals and can enter tissues well. Except for cerebrospinal fluid, the drug concentration in almost all tissues is higher than that in plasma. Liver metabolism is mainly to remove the ethyl group of the 7-piperazine ring to produce ciprofloxacin, followed by oxidation and glucuronic acid binding. It is mainly excreted through the kidneys (through renal tubular secretion and glomerular filtration), and 15%~50% is excreted in the urine in its original form. The elimination half-life varies greatly among different species of animals and different administration routes. The elimination half-life after intramuscular injection is 5.9 hours for cows, 9.9 hours for horses, 1.5 to 4.5 hours for sheep, and 4.6 hours for pigs.

Fluoroquinolone antibacterial drugs. Used for bacterial diseases and mycoplasma infections in livestock and poultry

Intramuscular injection: one dose, per 1kg body weight, 0.025ml for cattle, sheep, and pigs; 0.025~0.05ml for dogs, cats, and rabbits. Use 1 to 2 times a day for 2 to 3 days.